منابع مشابه
Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria
BACKGROUND Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. O...
متن کاملEarly proximal tubular dysfunction in Lowe's syndrome.
The early diagnosis of Lowe's syndrome can be difficult. Urinary excretion of retinol binding protein (RBP) and the lysosomal enzyme N-acetyl-glucosaminidase (NAG) were significantly increased in boys with Lowe's syndrome. Measurement of these urine parameters is recommended in suspected cases.
متن کاملLoad Dependence of Proximal Tubular Bicarbonate
Studies were undertaken in Munich-Wistar rats to determine whether maintenance of chronic metabolic alkalosis (CMA) is associated with an increase in proximal HCO3 reabsorption, or whether a reduction in glomerular filtration rate (GFR) is required to sustain the elevated plasma HCO3 concentration. Superficial single nephron glomerular filtration rate (SNGFR), and absolute proximal HCO3 (APRHCo...
متن کاملPDZ interactions and proximal tubular phosphate reabsorption.
In adults, the extent of renal reabsorption of P(i) and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P(i) cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditi...
متن کاملProximal tubular phosphate reabsorption: molecular mechanisms.
Renal proximal tubular reabsorption of P(i) is a key element in overall P(i) homeostasis, and it involves a secondary active P(i) transport mechanism. Among the molecularly identified sodium-phosphate (Na/P(i)) cotransport systems a brush-border membrane type IIa Na-P(i) cotransporter is the key player in proximal tubular P(i) reabsorption. Physiological and pathophysiological alterations in re...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2018
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.12001017